In fact, the human thyroid stimulating monoclonal autoantibody (TSmAb), referred to as “M22”, isolated from the peripheral blood lymphocytes of a patient with GO [5], was reported to increase the expression of IL-6 in orbital preadipocyte fibroblasts and the secretion of IL-6 by mature adipocytes [6]. This evidence concerns the gene IL6 and geroderma osteodysplastica.