Alzheimer disease (AD), the most common type of dementia, affects 4–8% of elderly individuals and is characterized by the accumulation of extracellular senile plaques and neuron fibrillary tangles (NFTs) primarily composed of amyloid-β (Aβ) and hyperphosphorylated microtubule assisted protein Tau (MAPT), respectively [1]. Here, MAPT is linked to Alzheimer disease.