NARS1 and pulmonary arterial hypertension: Considering the relevant role of NO in maintaining physiological integrity in various districts of human body, a decreased availability of NaRs enzymes can alter the nitrate-nitrite-NO pathway and affect availability of bioactive NO, with considerable consequences for individual’s overall health, including the development of human cardiovascular, pulmonary-vascular, neuromuscular, and metabolic diseases, such as arterial hypertension (AH), pulmonary arterial hypertension (PAH), Alzheimer’s disease, etc. [82,83].