The literature also describes other animal insulin-secreting cell lines used in diabetes mellitus research such as murine cell lines (β-TC-1, β-TC-3, IgSC195, βHC, NIT-1), rat cell lines (RINm, RINr, BRIN-BG5, BRIN-BG7, BRIN-BD11, CRI-G1, CRI-G1-RS, In-111) and hamster pancreatic β-cell lines (HIT-T15) [227,233], but to the best of our knowledge, the effect of EDC exposure on the development of obesity and metabolic disorders using these in vitro models has not yet been investigated. The gene discussed is INS; the disease is Obesity.