INS and obesity due to melanocortin 4 receptor deficiency: The literature also describes other animal insulin-secreting cell lines used in diabetes mellitus research such as murine cell lines (β-TC-1, β-TC-3, IgSC195, βHC, NIT-1), rat cell lines (RINm, RINr, BRIN-BG5, BRIN-BG7, BRIN-BD11, CRI-G1, CRI-G1-RS, In-111) and hamster pancreatic β-cell lines (HIT-T15) [227,233], but to the best of our knowledge, the effect of EDC exposure on the development of obesity and metabolic disorders using these in vitro models has not yet been investigated.