DHCR7-DT and neoplasm: Notably, the authors found strong correlations between volumetric PET parameters and the established serologic tumor biomarkers such as lactate dehydrogenase (LDH), S-100 protein, and inflammatory markers alkaline phosphatase (AP) and C-reactive protein (CRP), highlighting that tumor volumetric parameters may have important prognostic applications in clinical management of CM patients [254].