To further determine the potential function of SNAI2 during tumor initiation, SNAI2-modified SiHa cells and their control cells were subcutaneously injected into NOD/SCID mice by limiting dilutions to 10, 100, 1000, and 10,000 cells, and then the tumor volume, tumor initiating frequency, and incidence were monitored. This evidence concerns the gene SNAI2 and neoplasm.