KLK3 and Familial prostate cancer: However, a recent analysis of greater than 13,000 prostate cancer patients showed that lower ANO7 protein expression in radical prostatectomy samples is associated with unfavorable clinicopathological parameters, including higher tumor stage, Gleason score, and preoperative prostate-specific antigen (PSA) level, as well as presence of lymph node metastasis, a positive surgical margin, and earlier biochemical recurrence [19].