In nasopharyngeal carcinoma, LMP-1 increases the packaging of hypoxia-inducible factor 1α (HIFα) into EVs [113] and the secretion of EVs through syndecan-2 (SDC2) and synaptotagmin-like-4 (SYTL4)—NFκB pathway [117]. This evidence concerns the gene SYTL4 and nasopharyngeal carcinoma.