In a colorectal cancer model, iPSCs-derived colorectal cancer organoids were developed to test drug sensitivity, revealed that geneticin was able to suppress WNT signaling activation, rescue adenomatous polyposis coli (APC) protein expression levels, and suppressed the colonic epithelial proliferation in familial adenomatous polyposis colonic organoid model [88]. Here, APC is linked to colorectal cancer.