EP300 and familial pancreatic carcinoma: On the other hand, in pancreatic cancer, the p300/GATA6 axis determines differentiation and Wnt dependency, and loss of EP300 leads to a phenotypic transition from the classical subtype to the de-differentiated basal-like/squamous subtype of pancreatic cancer due to the attenuation of the GATA6-regulated differentiation program [75].