Recently, Hagiwara et al. [153] have demonstrated that an oncogenic protein, MUC1-C, that drives lineage plasticity in prostate cancer progression also integrates the activation of PBRM1 with the regulation of redox balance, pluripotency markers’ expression, and cancer stem cell-like state in pancreatic cancer. The gene discussed is PBRM1; the disease is familial pancreatic carcinoma.