In this study, we investigated potential therapeutic effects of growth hormone secretagogues (GHSs) in a simplified in vitro model, using the human neuroblastoma cell line (SH-SY5Y), which expresses the SOD1-G93A mutated protein, and treating these cells with H2O2 (150 μM) for 24 h, in order to mimic the increased oxidative stress environment typical of ALS [26,27]. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.