However, testing the association between the TCF7L2 rs7903146 variant and subtypes of T2D, determined according to various disease progression and clinical complications [48], has shown that rs7903146 was associated with severe insulin-deficient diabetes (SIDD), mild obesity-related diabetes (MOD), and mild age-related diabetes (MARD), but not with severe autoimmune diabetes (SAID) or severe insulin-resistant diabetes (SIRD) [49]. This evidence concerns the gene TCF7L2 and insulin-resistant diabetes mellitus.