The signaling transmission system of TLR is activated by MEK/ERK kinase and functions as cell cycle regulators, and an unregulated MEK/ERK kinase pathway can induce the tumor developments, which activates the transcription of PD-L1 mRNA, resulting in the expression of PD-L1 as a membrane protein of the tumor cell [12]. This evidence concerns the gene MAP2K7 and neoplasm.