Most recently, it was demonstrated that melanoma-derived exosomes with intercellular adhesion molecule 1 (ICAM-1) on their surface could interact with lymphocyte function-associated antigen 1 (LFA-1) upregulated in activated CD8+ T cells, which was required prior exosomal PD-L1-mediated immune suppression [76]. This evidence concerns the gene CD8A and melanoma.