TNF and Cowden disease: BL-7010 was shown to bind with high affinity to gliadin in vitro [79], to abrogate gluten-induced intestinal injury in vivo in rodent models [79,81], and to decrease tumor necrosis factor-α (TNF-α) secretion ex vivo in mucosal biopsies from CD patients in the presence of partially digested gliadin [81].