CARTPT and Tremor: Intrathecal (i.t.)administration of 0.1–0.3 nmol/rat CART(55-102) significantly decreased the mechanical hyperalgesia in the carrageenan-induced acute inflammation model (Figure 3), while i.t. 0.1–1.0 nmol/rat CART(62-102) had no antihyperalgesic effect The i.t. administration of more than 0.3 nmol/rat CART(55-102) and 1.0 nmol/rat CART(62-102), however, caused abnormal motor perturbances (ascending tremor) that prevented precise measurements.