Heatmap analysis in Figure 2 clusters the DASs into two principal clusters (C1 and C2): C1 highlights the highly abundant proteins in LC-IPF, such as HTP, ANXA3, TTHY, B2MG, FETUA, APOA1, CFAB, ALBU (fragment), S10A9, HBB, IGHG1, RET4, and PROF1, with the exception of TRFE which is the only protein species resulting as down-regulated. The gene discussed is ANXA3; the disease is idiopathic pulmonary fibrosis.