IDH1 and neoplasm: Furthermore, ROS accumulation in IDH1 (isocitrate dehydrogenase-1—a potent antioxidant) knockdown ovarian granulosa-like tumor cell line triggered the phosphorylation of ERK 1⁄2, JNK, and p38 and accelerated senescence, suggesting that ROS was responsible for cell cycle arrest via the MAPK signaling pathway [34].