PDGFB and Hyperglycemia: This finding leads us to deduce, first, that the biochemical interactions between endothelium and ASCs and their differentiated P-ASCs follow the physiological path of interlocution between ECs and PCs, based on the PDGF-B/PDGFR-β axis, and second, that this path is amplified in our condition of in vitro induced hyperglycemia.