GPER1 and cardiac hypertrophy: In this study, we investigated the role of GPR30 in the pathological cardiac hypertrophy of OVX mice, and our results include several important findings regarding the effect of GPR30 on myocardial hypertrophy and the mechanism behind it: (1) We found that cardiac hypertrophy was more significant in the OVX + TAC group than in the OVX and TAC groups.