Moreover, we found that anti-spike S1 IgA levels were significantly increased in non-transplanted CF patients upon vaccination both at T1 and T2, with similar median values of the Ratio of Absorbance (RoA) (4.2 and 3.5 at T1 and T2, respectively), thus well above the cut-off, which was set to 1.1 RoA. This evidence concerns the gene CD79A and cystic fibrosis.