Using several human tumor xenograft models, it was demonstrated that miRS -210/-155, HIF-1/2α, Nrf2, and regulated targets, PD-L1 and VEGF, are selenium targets, and their downregulation was associated with enhanced antitumor activity in multiple mouse models [53,54,55,56,57,105,106,107]. This evidence concerns the gene NFE2L2 and neoplasm.