The intent of this minireview was not to provide a comprehensive review of all targets altered in ccRCC but to illustrate that specific targets overexpressed in ccRCC, such as HIFS, miRs-210/-155, TGF-β, and Nrf2, which are targets that can be downregulated by nontoxic, clinically achievable selenium doses. The gene discussed is TGFB1; the disease is nonpapillary renal cell carcinoma.