CRC incidence in the group of 75–79 years decreased substantially (APC −7.3% [−10.4 to −4.1]) during 2014–2019 to a significantly lower rate compared to before the start of the screening programme (251.6/100,000 py in 2019 vs. 374.6/100,000 py in 2012). This evidence concerns the gene APC and colorectal carcinoma.