ACE2 and COVID-19: Conversely, there continues to emerge growing evidence on the long-term cognitive effects of COVID-19, which are mediated through the above-mentioned inflammatory pathways as well as hypoxia, and by means of direct binding to the angiotensin-converting enzyme 2 (ACE2), which is a prominent pathophysiological entry-point shared by respiratory epithelial cells and the olfactory nerve [39,40,49,50].