LGALS3 and heart failure: According to the NYHA functional classification, we discovered a noticeable decrease in the mean concentration of galectin-3 in class III heart failure, from 63.04 ± 20.79 to 50.76 ± 18.70 (p < 0.001) and lowered the most in the NYHA IV group, however, p = 0.05 due to the small sample size.