THBD and Sepsis: Although the analysis of all the included patients did not show any effect of AT on in-hospital mortality, the subanalysis of patients diagnosed with sepsis-associated DIC (ISTH criteria) demonstrated an independent association between AT and/or recombinant human thrombomodulin (rhTM) and lower in-hospital mortality than other anticoagulants (HR 0.74 (95% CI 0.60–0.92) [42].