GAST and gastric cancer: Similarly, different genes involved in extracellular matrix remodeling, such as MMP3 and collagen types 1, 3 and 5, are up-regulated, and some genes associated with aldehyde dehydrogenase and aldose A (hydrocarbon metabolism), ion transporters (gastric juice), mucin 5 (mucus production), and gastrin and somatostatin (gastric hormones) are down-regulated in this model of gastric cancer.