CASP3 and breast cancer: Chinese propolis water extract and its effective components induced apoptosis of breast cancer cells (MCF-7, MDA-MB-231, A549, and HeLa cells) by inhibiting tumor cell migration, activating caspase 3, and promoting ROS production when the concentrations of propolis and each of its effective components (pinobanksin, caffeic acid benzyl ester, caffeic acid phenethyl ester, apigenin, pinocembrin, chrysin, and galangin) were 100 μg/mL and 80 μM [37].