In a study on the human intrahepatic CCA cell lines HuCCT-1 and SSP-25, UA treatment-induced G2/M phase cell cycle arrest, thus repressing cell proliferation, and exerted anti-tumor effects by suppressing the Akt/WNK1 signaling pathway and inducing autophagy [159]. The gene discussed is WNK1; the disease is cholangiocarcinoma.