According to the number of genes affected, the most significant pathways were as follows: ApoE and miRNA-146 in inflammation and atherosclerosis (80%), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) actives NLRP3 inflammasome (67%), miRNA-124 interaction with cell cycle and differentiation (67%), and SARS-CoV-2 antagonizes innate immune activation (62%). The gene discussed is APOE; the disease is atherosclerosis.