The anti-inflammatory effect of PSLP in RAW264.7 macrophages is mainly involved in the following signaling pathways, including the HIF-1 signaling pathway, the FoxO signaling pathway, the ErbB signaling pathway, ubiquitin-mediated proteolysis, tight junction, renal cell carcinoma, proteoglycan in cancer, PD-L1 expression and PD-1 checkpoint in cancer, amino acid biosynthesis, etc. Among them were the most differentially expressed genes involved in the herpes simplex virus 1 infection pathway, a total of 236. This evidence concerns the gene CD274 and hereditary clear cell renal cell carcinoma.