It is also associated with an endogenous source-like corticotropin syndrome from ACTH-secreting extra pituitary tumors (endogenous Cushing’s syndrome) [17] or from an ACTH-secreting pituitary gland adenoma (Cushing’s disease) [29,30]. The gene discussed is POMC; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.