As the [TIMP2]*[IGFBP-7] biomarker require a few hours to be detected in the urinary sample (4 h to 12 h), and ICU admission with mechanical ventilation was frequently the culmination of a rapid deterioration from the ward with precipitating respiratory failure, the urinary specimen at 12 h, which were increased in this population, may be the optimal time-window to detect the clinical deterioration and early kidney damage in our population. Here, IGFBP7 is linked to Nephropathy.