Moreover, Lind Malte et al. assessed the performance of a combination of angiogenic and vasoactive biomarkers to predict the development of severe preeclampsia/HELLP syndrome in the third trimester of pregnancy, and determined that a combination of biomarkers (CT-pro-ET-1, sFlt-1, and systolic blood pressure) achieved an AUC of 0.94 for prediction of development of severe PE/HELLP syndrome within 1 week, and an AUC of 0.83 for prediction of their development within 2 weeks of evaluation [12]. Here, EDN1 is linked to HELLP syndrome.