To evaluate the correlations between pathological features with prognostic value, we assessed the associations between age at diagnosis, gender, pre-operative serum calcitonin levels, tumor size, location, growth pattern, stromal amyloid, mitotic activity/2 mm2, Ki67 proliferation index, tumor necrosis pathologic T category, AJCC stage, coexisting thyroid pathology, and five elements considered to be essential for risk stratification, namely, PNI, LVI, mETE, multifocality, and LNM (Table S1). This evidence concerns the gene MKI67 and neoplasm.