AFP and hepatocellular carcinoma: By multivariate analysis adjusted for age, gender, and CTP class, we found that acetone dimer and AFP were significantly associated with HCC, with adjusted odd ratios (OR) of 9.29 (95%CI: 2.34–36.79) and 1.42 (95%CI: 1.06–1.88), respectively, p < 0.001 and 0.006.