Although a few studies have mentioned that plasma NT-proBNP levels would be higher in patients with poor renal function [12], Tsutamoto (2019) found that plasma NT-proBNP concentration is unaffected by eGFR in non-CKD patients with an eGFR > 60 mL/min/1.73 m2 [13]. The gene discussed is NPPB; the disease is chronic kidney disease.