NKX2-5 and familial dilated cardiomyopathy: To date, DCM-causative mutations in over 250 genes have been involved in the molecular pathogenesis of DCM, of which the vast majority encode sarcomeric proteins, Z-disk proteins, desmosomal proteins, cytoskeletal proteins, nuclear envelope proteins, sarcolemma proteins, intercalated disc proteins, RNA-binding proteins, mitochondrial proteins, gap junction channel proteins, ion channel proteins, and transcriptional factor proteins, including NKX2.5 and TBX20 [1,2,20,21,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56].