Here, the Gln56*-mutant BMP10 + wild-type BMP10 group was conducted in vitro to mimic the pathogenic status of the DCM patients harboring the heterozygous BMP10 mutation; the wild-type BMP10 group and the wild-type BMP10 + Gln56*-mutant BMP10 group were performed to explore the potential dominant-negative effect of Gln56*-mutant BMP10 on wild-type BMP10, and the results suggested no dominant-negative effect of Gln56*-mutant BMP10 on wild-type BMP10. The gene discussed is BMP10; the disease is familial dilated cardiomyopathy.