The proband of Family 1 (III-5) was initially diagnosed with DCM at the age of 36 years and received pharmacologic therapies for congestive heart failure, including β-adrenergic receptor antagonist (metoprolol), angiotensin-converting enzyme inhibitor (enalapril), and diuretics (furosemide and spironolactone). This evidence concerns the gene ACE and congestive heart failure.