MYOCD and heart failure: In addition, the MYOCD/BMP10 signaling pathway has been discovered to be required for proper cardiac growth, chamber maturation, and embryonic survival, and Myocd-null embryos showed myocardial hypoplasia, defective atrial and ventricular chamber maturation, heart failure, and embryonic lethality, which were caused in part by a block in the BMP10 signaling [88].