The results of these different experiences may appear controversial; in reality, it is hard to compare studied with a huge difference in the definition of malignancy and aggressiveness of PTEN; while Fujimori [14] considered aggressive G2/G3 tumor as the definition on 2010 PTENs by the WHO, Ishikawa [26] and Pais [27] considered aggressiveness according to the 2004 WHO PTEN classification. This evidence concerns the gene PTEN and neoplasm.