CD274 and colorectal carcinoma: This finding was consistent with a recent Wang et al. meta-analysis, in which the meta-regression showed that “PD-L1 expression played a significant role on poor CRC OS (HR  =  1.95, 95% CI (1.92, 3.98)) and DFS (HR  =  2.14, 95% CI (0.73, 4.52))” and could independently predict a poor CRC prognosis [45].