As regards the association of BRAF protein expression with the clinicopathological characteristics of the studied colonic adenocarcinoma cases, using a two-sided Chi-square test, there were significant associations with grade III (p = 0.04), N1 (p = 0.00), advanced Dukes stage (C-D) (p = 0.02), presence of relapse (p = 0.02), and shorter overall survival (OS; p = 0.00). This evidence concerns the gene BRAF and colon adenocarcinoma.