An antibody panel consisting of hepatocyte paraffin 1, arginase-1, monoclonal carcinoembryonic antigen, CK7, CK20, TTF-1 (positive cytoplasmic staining in HCC, positive nuclear staining in lung adenocarcinoma), and CDX2 (positive nuclear staining in intestinal adenocarcinoma) could be used to optimize the differential diagnosis of HCC, metastatic adenocarcinoma, and CCA [82]. The gene discussed is ARG1; the disease is lung adenocarcinoma.