Univariate Cox proportional hazard regression identified age (HR 1.07, p = 0.003), body surface area (HR 0.08, p = 0.055), active cancer (HR 5.59, p = 0.003), chronic renal failure (HR 6.35, p < 0.001), chronic liver disease (HR 8.03, p = 0.007), P/F at presentation (HR 0.99, p = 0.096), LVEF (HR 0.99, p = 0.891), A wave velocity (HR 1.02, p = 0.042), Mitral medium e’ velocity (HR 0.78, p = 0.070), sPAP (HR 1.03, p = 0.061) and ePLAR (HR 4.50, p = 0.047) associated with an increased risk of death. The gene discussed is PDZK1IP1; the disease is chronic kidney disease.