For instance, PAK5 and YAF2, which promote cell migration and invasion, were overexpressed in the leiomyosarcoma sample; while WIF1, a marker of osteoblastic differentiation, and DLK1, which is involved in cancer stem-like cell maintenance and cancer differentiation, were upregulated in the osteosarcoma sample. This evidence concerns the gene WIF1 and osteosarcoma.