We can therefore assert that hemoglobin concentrations at the lower limits of normal (according to the WHO criteria) have a general negative impact on mood, functional capacity, malnutrition, and comorbidities, but since a worsening of the affective-functional-nutritional status and the comorbidities emerged in subjects with anemia compared to the counterparts without anemia already with Hb < 13 g/dL for both genders, it would be possible to consider this cut-off to identify anemia in the elderly. This evidence concerns the gene GSTM1 and nutritional deficiency disease.