Based on the actual PCOS and/or polycystic ovaries diagnostic guidelines [98] and given that women with polycystic ovaries also may have high AMH levels [99], the diagnostic AMH cut-off value(s) may depend on the age and phenotype as a worsening variable that complicates the detection of polycystic ovaries [100]. This evidence concerns the gene AMH and polycystic ovary syndrome.