SOX2 and cancer: Similar to ClinVar, where variants were enriched within the HMG box of several proteins, cancer somatic variants also showed an HMG box enrichment for SOX11, SOX9, SOX4, SOX10, SOX1, SRY, SOX18, SOX21, SOX3, SOX12, SOX14, SOX17, SOX2, and SOX13 (cyan, Figure 7A).