TUG1 and familial dilated cardiomyopathy: It is up-regulated in the DCM mouse model based on the intraperitoneally injection of streptozotocin (an antibiotic that produces pancreatic islet β-cell destruction [95]), while down-regulation of Tug1 improved cardiac function and myocardial fibrosis in the DCM mice by decreasing the levels of extracellular matrices (e.g., collagens).