APOE and atherosclerosis: These phenotypes were also observed in apolipoprotein E deficient (apoE)−/−mice on a C57BL/6J genetic background fed with a Western diet (a defined mouse model of atherosclerosis as well as non-alcoholic steatohepatitis [59,60]), where overexpression of FXYD6-AS1 increased proinflammatory cytokine production and augmented atherosclerotic lesions.