Not surprisingly, several lncRNAs are shown to be in the BMI-associated loci, such as LncOb rs10487505 variant between BMI and leptin level in pediatric non-alcoholic fatty liver disease [32], lncRNA transcript of the transcription factor 7 like 2 (lncRNA-TCF7L2) between BMI and biopolar disorder [33], MCHR2 antisense RNA 1 (MCHR2-AS1) between BMI and psychiatric patients [34], and the hypermethylation of the promoter of the lncRNA, TSPOAP1, SUPT4H1and RNF43 antisense RNA 1 (TSPOAP1-AS1), associated with obesity in overweight and obese Korean individuals [35]. The gene discussed is TSPOAP1; the disease is obesity due to melanocortin 4 receptor deficiency.