DEPDC5 and isolated focal cortical dysplasia type II: For example, a maternally inherited DEPDC5 nonsense variant was detected in a blood sample by capture sequencing, while a second nonsense somatic variant was detected by conventional Sanger sequencing in the postoperative brain tissue of child with focal cortical dysplasia type II (FCORD2; OMIM: #607341) [46] (Table 1).