ALPL and hypophosphatasia: When the causative homozygote duplication was identified by qPCR after the negative results of the Sanger sequencing, the life-saving ERT for a severe hypophosphatasia (HPP) (HPPC; OMIM: #241510/HPPI; OMIM: #241500/HPPA; OMIM: #146300) patient was started, and the symptoms such as respiratory failure improved during the treatment [42].