ALPL and hypophosphatasia: For example, while no mutation could be identified in the ALPL gene in a patient with autosomal recessive hypophosphatasia (HPP) (HPPC; OMIM: #241510/HPPI; OMIM: #241500/HPPA; OMIM: #146300), quantitative polymerase chain reaction (qPCR) analysis found a novel homozygote duplication encompassing exons 2 to 6 of ALPL after negative results by ES [42] (Table 1).