Regarding the incidence of germline MITF p.E318K variants in RCC, Shuch and colleagues reported that 0.7% (9 of 1235) of RCC patients who underwent a renal panel test for hereditary kidney-cancer-causing genes (RenalNext) were found to have germline MITF p.E318K variants [41]. The gene discussed is MITF; the disease is renal cell carcinoma.