MiT family translocation renal cell carcinoma (tRCC) is a sporadic RCC characterized by fusion genes involving the MiT/TFE family genes, MITF, TFEB, and TFE3 and defined as an MiT family translocation RCC in the 2016 WHO classification [10,11]. The gene discussed is TFEB; the disease is renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.