All over the world, a total of eleven types of HPS have been reported that are caused by mutations in AP-3, BLOC-1, BLOC-2, and BLOC-3 protein complexes, while from Pakistan, only three reports have been made so far that reported HPS1, HPS3, HPS4, HPS6, HPS8, and HPS9 types. This evidence concerns the gene HPS4 and Hermansky-Pudlak syndrome.